SynthDose - More Drugs

⭐ ⭐⭐ (1,306 endorsements) 📥 708,347 downloads 📌 v1.3.9 📅 4/7/2024
🟠 Updated over a year ago

By Phoenicia · Gameplay

⬇ Download Mod Source: Nexus Mods 📅 Updated: 3/19/2025 📅 Created: 4/7/2024
⚠️ Install Order · 6 steps
1🛠️ Cyber Engine Tweaks — Cyber Engine Tweaks (CET) Download ↗
2🛠️ RED4ext — RED4ext (native plugin loader) Download ↗
3🛠️ redscript — redscript (scripting framework) Download ↗
4🧩 ArchiveXL — ArchiveXL (archive loader) Download ↗
5🧩 TweakXL — TweakXL (tweak framework) Download ↗
6🧩 Codeware — Codeware (UI framework) Download ↗

Install in this order, then this mod last — most mods fail to load without their framework and dependencies in place.

🔍 Analysis

  • 👍 0.2% endorsement rate
  • 🏆 #134 of 457 Gameplay mods in this game by downloads

📋 About This Mod

Drugs:

All drugs, all treated as inhalers / injectors, and share cooldown / item slot with it. Each drug has unique effects and toxicity levels, potentially leading to debuffs or health damage upon overdose. These drugs are available from various vendors, with a full selection available at Dogtown Stadium. Note that purchasing illegal drugs outside of Dogtown requires street cred.

Toxicity System: 

By default, all drugs added by this mod, will cause player toxicity to raise. Player toxicity levels are displayed as a bar below stamina bar.

Going over 50% toxicity treshold, will apply some maluses to player. Player will also take damage scaling with toxicity too. Going over the toxicity cap is possible as well, but it will deal massive damage, relative to toxicity of taken drugs. Toxicity will slowly fade to 0, when not consuming drugs.

Being poisoned by enemies, will also slowly raise toxicity.

Leveled Drugs (Can be bought at tiers 1-5+):

  • []SuperJet - Last Stand kind of drug. Massive initial heal, and damage reduction, tapering off over short time period.

    It also gives adrenaline on hit,  but disables any futher healing item use. []IC3C0LD - Offers instant RAM regeneration and increased RAM regen, ideal for early game before unlocking Overclock.

    []Roaring Phoenix -A slightly less powerful version of Blood Pump.

    []Be Rite Back - A weaker MaxDoc with added Cyberware Cooldown Reduction.

    General Drugs:
    • []K - Enhances the Kerenzikov Effect, making it longer and stronger.

    []Glitter -Significantly boosts movement speed, attack speed, and jump, but with high toxicity that can be fatal.

    []Breathless - Eliminates stamina regeneration delay.

    []StimPack - Reduces recoil, and enhances accuracy, reload speed, crit chance, and movement speed.

    []Aspis - Greatly increases armor and health but reduces movement speed and mobility.

    []Juice - Maximizes adrenaline and prevents its decay, with additional buffs to movement speed, melee damage, and jumping—ideal as healer replacement for high HP/melee builds.

    []Elude -Provides a small mitigation buff at the cost of armor, with added movement speed and stealth benefits.

    []Marinette - Extends quickhack trace time and increases quickhack damage.

    []Black Lace - Grants armor and, during Adrenaline Rush, provides additional armor and a damage bonus.

    []Code Freeze - Reduces the health cost of quickhacks during Overclock.

    []Rambo 8 - Significantly boosts melee damage at the cost of melee speed and increased stamina use, along with bonuses to Body attribute checks.

    []Happy Kill -Restores health and RAM on kill, guarantees a 'Edgerunner' buff post-kill, and provides additional stacking buffs for each kill.

    Cyberware:

    [*]Detoxifier: Can be used, to

🤖 AI-enhanced — based on mod data

SynthDose - More Drugs adds 15 new drugs to Cyberpunk 2077, introducing a toxicity mechanic and cyberware to manage it. With over 1,300 endorsements and 700k downloads, it's a popular gameplay expansion for players seeking deeper substance-use systems.

✨ Key Features

Adds 15 new drugs to the game
Introduces a toxicity effect mechanic
Includes cyberware specifically for handling toxicity

📊 Pros & Cons

✅ Pros

  • Huge community trust (1,306 endorsements) and massive adoption (708k downloads)
  • Adds meaningful gameplay depth with a toxicity system that makes drug use riskier
  • Cyberware integration gives players a way to counterbalance the new mechanic

⚠️ Cons

  • Last updated March 2025 — may not be compatible with future game patches
  • Requires understanding of toxicity mechanics, which could be overwhelming for new players
🎯 Is This For You?
For Cyberpunk 2077 players who want to expand the game's substance-use systems with more variety and risk-reward gameplay. Perfect for roleplayers and completionists who enjoy crafting and managing debuffs. Skip if you prefer a pure vanilla experience or don't want to deal with extra mechanics.
📦 Install:Easy· Under 1 minute

💡 Beginner Tips

  • If you're using a mod manager like Vortex, install via the manager to keep track of updates and conflicts.
  • Check the mod's page for any required dependencies or patches, as the description doesn't list them.
  • Before installing, back up your save files to avoid corruption if the mod conflicts with other gameplay mods.

📊 Mod Details

Game
Cyberpunk 2077 Mods
Author
Phoenicia
Version
1.3.9
Downloads
708,347
Endorsements
1,306
Category
Gameplay
Created
4/7/2024
Updated
3/19/2025

🔧 How to Install Cyberpunk 2077 Mods

Download from Nexus.

📖 Full step-by-step install guide for Cyberpunk 2077 →

Visit the official mod page for specific installation instructions for this mod.

🎮 Need cheat codes or console commands? Check ur gaming wiki for Cyberpunk 2077 commands, item IDs, and more.

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