Mutations

Mutations

Transform your runs with Mutations, a Custom Run modifier for Slay the Spire 2 that introduces high-stakes strategic deckbuilding through permanent character alterations.

Also on Steam Workshop for subscribe-and-play install.

Core mechanics

• []The mutation budget: start with 1 point to spend on powerful character buffs. Positives cost. Negatives refund.[/]

  []The risk/reward trade-off: take permanent drawbacks to unlock more budget for stronger or extra buffs. You do not need matching positive and negative counts.[/]

  []Run-long permanence: the mutations you choose stick through every floor, elite, and boss until the run ends.[/]

  Key features

  • []Custom Run modifier: tailored difficulty and creative builds[/]

    []Synergy creation: combine unique positive traits with crippling constraints[/]

    []Deep replayability: every run is a puzzle of how much handicap your deck can handle for extra power[/]

    How to get started

    • []Download the main file. Extract the Sts2Mutations folder into Slay the Spire 2\mods\ (fully restart STS2 after install or update).[/]

      []Start a Custom Run.[/]

      []Enable the Mutations modifier.[/]

      []Select your hero, pick your mutations, and start climbing.[/]

      With Infinite Ascent

      Install this mod and Infinite Ascent. Enable Infinite Ascent and Infinite Ascent: Mutations. Do not also enable the standalone Mutations modifier.

      After Act 4+ act bosses, the Spire rewrites your mutations (1 Gift + 1 Flaw). The first rewrite is required. Later you can decline and keep what you have.

      At a glance

      • []111 mutations in the Compendium (95 in the picker for one character, plus other heroes' signatures)[/]

        []Mutations Compendium: press F8 or use the top-bar button during a run (use/win stats)[/]

        []Character-gated picks (Silent: Toxic Gambler; Ironclad: Cleave)[/]

        []Unstable Genome auto-only at 4+ positives or 4+ negatives (hidden random combat mutation each fight)[/]

        []Full localization for STS2 interface languages[/]

        []All characters supported on Custom Run[/]

        []Currently not supported for multiplayer[/]

        v0. 9. 10 (beta) for STS2 public-beta (v0. 110.x / v0. 111. 0). This file is for the public-beta game branch. Game updates may require a mod update.

        Links

        Steam Workshop | Discord | Patreon

        Fan-made mod. Not affiliated with Mega Crit.