Poisonous Poisons
⚪ Last updated 2018⚠️ Install Order · 5 steps
Install in this order, then this mod last — most mods fail to load without their framework and dependencies in place.
Preview

🔍 Analysis
- 👍 3.0% endorsement rate — high engagement, a strong quality signal
- 🏆 #375 of 435 Gameplay Effects and Changes mods in this game by downloads
📋 About This Mod
Poisonous Poisons
REQUIRES (almost) ALL DLC
REQUIRES JIP LN
This mod started as a personal pet peeve of mine, seeing as tribal and makeshift remedies like Antivenom was pretty much everything that the world of New Vegas knows about poison treatment, and somehow they have an amazingly wide spectrum of effectiveness. Looking around the Nexus for inspiration, I first came across MadCat's Antidotes mod, which offers a pair of new ingestibles to immunize your character for a short time prior to a fight against Cazadores or Scorpions. Not much, but an excellent start. I also noticed that going by the game file's names, the different bottle models used for the weapon poisons in New Vegas were initially intended for such a system, having different antidotes against different enemies, before they decided to dump them all together into antivenom.
I also wanted for being poisoned to actually matter somewhat, even if curing poisons was ultimately easy, for it to actually be able to affect your character in nasty ways, and take an awful lot of time and pain to clear out so that waiting it out would be simply impractical. Like in the classic Fallout games, where getting poisoned by a radscorpion sting ultimately didn't do much, but the effect could last even several days if you didn't take antidote.
Finally, as for the bottled poisons you can use in melee, I also wanted them to have more interesting effects and be included by the above ideas as well, something for which I drew inspiration from Alceister's Poison Overhaul mod, adding a new perk to make poisons and the Medicine skill more useful.
In this mod I've touched a lot of stuff, and while I believe the end result can still be improved (of course), hopefully you'll find that poisons are now something more of a menace... well, at least if you let them touch you and don't go swimming in Antivenom; and that if you favor the Medicine skill you might have more fun with them as well.
Poison Buff and Overhaul
All poisons should now be simply terrible for you and your enemies. Bottled poisons had their effects buffed up, and in some cases new effects were added. Mother Darkness will drain the target's movement speed, Bleak Venom will damage or cripple the chest, Dark Datura drains Agility and Action Points whether you or White Legs use it. Tremble will cause the target to trip and fall due to violent shakes every few seconds, even dropping any non-Unarmed weapon he has drawn, making it more useful against both creatures and NPCs. All poison recipes are categorized under a new subcategory in the Campfire menu.
Animal poisons are even worse. Green Gecko and Tunneler poisons were restored which will drain your Strength and cripple your legs respectively. Green Gecko poison
Poisonous Poisons overhauls poison mechanics in the game, making them significantly more dangerous and forcing players to carry antivenoms and antidotes. It also grants more enemies the ability to poison the player. With 180 endorsements and 5,956 downloads, it's a niche but appreciated gameplay mod, last updated in 2018.
✨ Key Features
📊 Pros & Cons
✅ Pros
- Turns poison from a minor nuisance into a real threat that demands respect.
- Adds pressure to prepare properly — you'll actually need those antidotes now.
- Decent community support with 180 endorsements and nearly 6k downloads.
⚠️ Cons
- Last updated in 2018 — might be outdated for current game versions.
- Could be frustrating if you prefer a more casual experience — poison becomes deadly.
For survival-minded players who want a tougher challenge and enjoy managing resources like antidotes. If you're a completionist who likes to be prepared for anything, this mod adds meaningful depth. Skip it if you prefer a more relaxed playthrough or don't want to worry about poison constantly.
💡 Beginner Tips
- Always keep a stock of antivenoms and antidotes in your inventory — you'll need them.
- Watch out for new poison-inflicting enemies; they can catch you off guard.
- If you're playing on a modded setup, test this mod in a separate save to see how it interacts with other gameplay overhauls.
📊 Mod Details
- Game
- New Vegas Mods
- Author
- migck et weijiesen
- Version
- 1.4
- Downloads
- 5,956
- Endorsements
- 180
- Category
- Gameplay Effects and Changes
- Created
- 12/30/2017
- Updated
- 9/28/2018
🔧 How to Install New Vegas Mods
Download from Nexus.
📖 Full step-by-step install guide for New Vegas →
Visit the official mod page for specific installation instructions for this mod.
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