MUTATION

⭐ ⭐ (560 endorsements) 📥 92,249 downloads 📌 v4.0.4 📅 3/10/2024
🟡 Updated this year

By bp42s · Gameplay

⬇ Download Mod Source: Nexus Mods ↗ 📅 Updated: 5/25/2026 📅 Created: 3/10/2024
⚠️ Install Order · 2 steps
1🛠️ F4SE — Fallout 4 Script Extender Download ↗
2🔧 UFO4P — Unofficial Fallout 4 Patch Download ↗

Install in this order, then this mod last — most mods fail to load without their framework and dependencies in place.

🔍 Analysis

  • 👍 0.6% endorsement rate
  • 🏆 #68 of 185 Gameplay mods in this game by downloads

📋 About This Mod

TO IMPROVE IS TO CHANGE. TO BE PERFECT IS TO CHANGE OFTEN.

OVERVIEW

- BECOME A MUTANT: Gain the chance to mutate in a variety of unique ways when exposed to radiation.

- REACTIVITY: Humans and Ghouls alike will comment on you when you have mutations.

- SERUM CRAFTING: Recover from mutations and kill legendary enemies to unlock the ability to craft your own mutation serums.

- CHARACTER CUSTOMIZATION: Unlock a small handful of exclusive eye colors as you gain and lose mutations.

- GHOULIFICATION INTEGRATION: Automatically accounts for ghoulified players with adjusted mutation radiation rates and more.

FEATURES

You have a chance to mutate whenever you take radiation damage. Mutations have a wide variety of positive and negative effects, much like Traits. There are 24 different mutations, each with their own combination of benefits and detriments.

- Mutations have a chance to be cured by using RadAway, and have a 100% chance to be cured when using MutateAway.

- You become eligible for mutations after reaching level 5, and only when you have at least 100 points of radiation.

- You can only mutate once every 90 real-life minutes. You can reset this cooldown by consuming a Mutated Growth.

CLASS FREAK

You can force your body to adapt to your mutations and reduce their negative effects through repeated exposure.

Class Freak is earned by gaining and recovering from an amount of unique mutations. Class Freak permanently reduces the negative effects of each mutation and unlocks the ability to craft mutation serums.

SERUM CRAFTING

Whether mutant or purist, smoothskin or scabskin, as you explore the Commonwealth, you will encounter legendary enemies. All legendary enemies now have a small chance of dropping Mutated Growths.

After earning Class Freak, you can begin to use Mutated Growths to craft mutation serums at Chemistry Stations.

Mutation serums instantly apply their specified mutation and fully suppress the downsides of that mutation for one real-life hour. Mutation serums cannot be found at vendors or sold to vendors.

GENE STARCHER

The Gene Starcher allows you to lock in your current mutations, preventing you from rolling new mutations and preventing you from removing mutations with RadAway or MutateAway.

The Gene Starcher can be cra

🤖 AI-enhanced — based on mod data

MUTATION brings Fallout 76's dynamic trait system to Fallout 4, letting you build your character with mutations. It includes serum crafting, custom icons, and several new mutations. With 560 endorsements and 92,249 downloads, it's a popular gameplay overhaul for players seeking new character builds.

✨ Key Features

Adds Fallout 76's dynamic trait system to Fallout 4.
Includes serum crafting for mutations.
Features custom icons for mutations.
Introduces several new mutations not in the base game.

📊 Pros & Cons

✅ Pros

  • Solid community traction with 560 endorsements and 92k downloads.
  • Brings a fresh character-building layer inspired by Fallout 76.
  • Serum crafting adds a new gameplay loop for mutation management.

⚠️ Cons

  • May conflict with other gameplay mods that alter perks or traits.
  • Requires Fallout 76 knowledge to fully appreciate the system.
  • No detailed description provided, so setup specifics are unclear.
🎯 Is This For You?
For Fallout 4 players who want to experiment with Fallout 76-style mutations and build variety. If you enjoy character customization and new gameplay mechanics, this is a solid pick. Skip if you prefer vanilla gameplay or dislike trait systems.
📦 Install:Easy· 5-10 minutes

💡 Beginner Tips

  • Plan your mutations around your playstyle—some have trade-offs.
  • Craft serums early to control which mutations you get.
  • Check for compatibility patches if you use other perk overhauls.

📊 Mod Details

Game
Fallout 4 Mods
Author
bp42s
Version
4.0.4
Downloads
92,249
Endorsements
560
Category
Gameplay
Created
3/10/2024
Updated
5/25/2026

🔗 Required By 1 Mod

These mods list this mod as a dependency.

🔧 How to Install Fallout 4 Mods

Download from Nexus.

📖 Full step-by-step install guide for Fallout 4 →

Visit the official mod page for specific installation instructions for this mod.

🎮 Need cheat codes or console commands? Check ur gaming wiki for Fallout 4 commands, item IDs, and more.

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